Real Madrid look to extend their lead over Barcelona to eight points when they face Real Mallorca on Saturday night.
Barca aren't in action until Sunday when they take on Real Betis, offering Real an opportunity to temporarily move comfortably clear.
The capital club boast the best away record in the league this season, picking up 22 points from a possible 27 on the road.
Madrid will be without Germany midfielder Sami Khedira after he suffered a sprained ankle against Malaga, while Angel Di Maria is a doubt.
Mallorca welcome striker Marvin Ogunjimi back to the squad after an ankle injury and he could make his La Liga debut this evening.