Monday evening's live streaming Championship clash sees Southampton play host to Leicester at St Mary's Stadium.
This is the 70th league fixture between these clubs. Southampton have won 27 and drawn 24 to date.
Leicester won the reverse fixture 3-2 in August but have never won at St Mary's.
Spanish midfielder Yago Falque could make his debut for the hosts after joining the Saints on loan from Tottenham.
Star striker Rickie Lambert is suspended so David Connolly and Guly Do Prado look set to continue in attack.
The Saints will be without the services of midfielder Richard Chaplow (knee) and defenders Dan Seaborne (head) and Radhi Jaidi (knee).
Midfielder Andy King is out for Leicester, while defensive pair Sol Bamba and John Pantsil are on African Nations Cup duty with Ivory Coast and Ghana respectively.
