Leicester cannot qualify for the quarter-finals of the Heineken Cup but they will be looking to end their Pool Four campaign on a high note when they entertain Aironi.
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Leicester are third in Pool Four with 12 points after three wins from five matches, while Aironi are rock bottom after failing to win any of their five games.
The Tigers, who could still qualify for the Amlin Challenge Cup, will hand scrum-half Micky Young his first start for the club, while Billy Twelvetrees joins Anthony Allen in midfield.
Leicester skipper Geordan Murphy will be making his 73rd appearance in the Heineken Cup, while Dan Cole and George Ford will start from the bench.
Aironi have been the whipping boys in Pool Four and will be going all out not to end their campaign without a single victory.
Coach Franco Smith has made seven changes to his team with Alberto Benettin, Gabriel Pizarro and Giovanbattista Venditti replacing Andrea Masi, Alberto Benettin and Sinoti Sinoti respectively in the back-line.
In the forwards there are four more changes with Simone Favaro, Roberto Santamaria, Fabio Staibano and Alberto de Marchi all getting the nod.
The Tigers are overwhelming favourites to win this game and end their campaign on a high note and they can be backed at 1/150 odds-on with
Bet365, while Aironi are an 18/1 shot. The draw can be backed at 50/1.
The bottom club are there for a reason and once again they have been handed no chance to break their duck. They have been given a 28 point start on the handicap market at 10/11.