Leicester can move to the top of Pool Four in the Heineken Cup if they beat current leaders Clermont and Ulster fail to get a bonus point win at Aironi.
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The Tigers are third on the ladder with eight points after winning two of their three matches, while Clermont are top of the pool with 10 points.
Last time out the Tigers crashed to a 30-12 defeat away at Clermont and will be looking to repay the favour on home soil.
Leicester director of rugby Richard Cockerill has recalled Thomas Waldrom to his starting XV while Boris Stankovich and Ben Woods have been named on the bench.
Clermont have made seven changes to their line-up. David Skrela and Regan King have been added to the back division, while Jason White, Jamie Cudmore, Ti'i Paulo, Lionel Faure and Clement Ric form a new-look front-five.
Leicester are seen as the favourites to win this game and can be backed at 4/9 with
Bet365, while Clermont are 9/5 to make it back-to-back wins against the Aviva Premiership side. The draw is on offer at 20/1.
Double result betting is very popular in the Heineken Cup and you can back Leicester to be ahead at half-time and full-time at 10/11, while they are 11/2 to be behind at the interval before hitting back to win the match.
Leicester need to be clinical in the final third today and if they are they are fully capable of walking away with a convincing victory. They are 13/2 to take the game by 11-15 points, while the visitors are 25/1 to romp away themselves by 21-25 points.